development of sm-153 chitosan for radiosynovectomy
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abstract
introduction: developing new radiosynovectomy agents is of great importance due to the aging of human populations around the world and increasing the incidence of inflammatory diseases. in this work, sm-153 chitosan agent was developed for the first time in our country and preparation and quality control of the compound is described. methods: sm-153 chloride was obtained by thermal neutron flux (4-5 × 1013 n.cm-2.s-1) of natural sm2o3 sample, dissolved in acidic media. 153sm-samarium chloride (370 mbq) was used in preparation of 153sm-chitosan complex followed by quality control using meoh: h2o: acetic acid (4: 4: 2) as mobile phase. the complex stability and viscosity were checked in the final solution up to 2 days. the complex solution and 153sm3+ (80 µci/100 µl) were injected intra-articularly into male rat knee joint followed by scarification studies 6 d post injection. results: sm-153 chitosan was prepared successfully with high radiochemical purity (>99%, itlc) at room temperature after 10-30 min followed by autoclave sterilization. the complex was stable at room temperature and 37ºc up to 2 days. no significant leakage of dose from injection site and its distribution in organs were observed up to 6 days for 153sm-chitosan. conclusion: approximately, more than 90% of injected dose remained in injection site after 6d. the complex is a dedicated agent for radiosynovectomy. the experience from this study would lead to the development of more sophisticated radiosynovectomy radiopharmaceutcals for human use in the country.
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Journal title:
iranian journal of nuclear medicinePublisher: tehran university of medical sciences
ISSN 1681-2824
volume 18
issue 1 2010
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